Bipolar Research Studies

Age: 18+
Location: Nationwide

We are seeking individuals who have been diagnosed or have all the symptoms of bipolar disorder, who also have family members with depression or mania. Our study asks individuals suffering from Bipolar Disorder and their family members suffering from mood disorders to undergo a 2-4 hour diagnostic interview and provide a small blood sample. Each participant will be compensated $75. Travel is not required. We can accommodate participants from all over the country. The study is ongoing until 2010. Please call 866-51-GENES (866-514-3637) or e-mail Ben Romanos at bromanos@yoda.bsd.uchicago.edu.   You may also visit us at http://www.ucfamily.org for more information.

Posted: 25 July, 2008

Are you living in the shadow of bipolar depression?

Age: 18+
Location: Litchfield Park, AZ

As a person with bipolar 1, you know what it’s like to live with the darkness of depression. So you may want to know about this clinical research study examining an investigational drug for bipolar depression compared to placebo, an inactive substance, when used in combination with a mood stabilizer, if you:

-Are at least 18
-Have been diagnosed with bipolar 1 and are experiencing a depressive episode
-Have a history of at least 1 manic or mixed episode

Participation may last up to 12 weeks, and includes study-related care and monitoring from specialists in bipolar 1, access to a mood stabilizer, and potential access to the investigational medication, all at no cost.

To learn more, please contact Judith Engelman, MD at: Dedicated Clinical Research, 14044 W. Camelback Road #216, Litchfield Park, AZ 85340 or (623)-245-6501

Posted: 8 July, 2008

Norepinephrine and Impulsivity

Do you or someone you know suffer from:

• Excessive energy?
• Inability to sleep?
• Spending too much money?
• Extreme irritability?
• Rapid speech or thoughts?
• Severe or frequent mood swings?
• Impulsive behavior?
• Been diagnosed with bipolar disorder or recently hospitalized?

If you answered "yes" to any of these questions, you may qualify for an ongoing research study of bipolar disorder.  The University of Texas Mental Sciences Institute is now seeking individuals to participate in a research study on bipolar disorder.  Qualified participants will be compensated for their time.  For more information please call (713) 500-2635.

Posted: 3 December 2007

Study of Lithium for the Treatment of Pediatric Mania

Is your child between 7-17?

Does s/he have excessive energy?

Irritability?

Mood swings?

Ever been diagnosed with Bipolar I disorder?

If so, your child may be eligible to participate in a clinical research program and receive study related examinations, lab tests, and medication at no cost from a doctor specialized in adolescent mental illness.

There may be an enrolling site near you.  Please see below for sites and contact information.

University Hospitals Case Medical Center, Cleveland, OH-- Dr. Robert Findling (216) 844-3922

Cincinnati Children's Hospital, Cincinnati, OH-- Dr. Robert Kowatch (513) 636-0160

The Zucker Hillside Hospital North Shore, Long Island, NY-- Dr. Vivian Kafantaris (718) 470-8362

The University of Illinois, Chicago, Chicago, IL-- Dr. Mani Pavuluri (312) 413-1722

University of North Carolina at Chapel Hill, NC-- Dr. Lin Sikich (800) 708-0048

Children's Hospital and Regional Medical Center, Seattle, WA-- Dr. J. McClellan (206) 987-3399

Cambridge Hospital, Cambridge, MA-- Dr. Jean Frazier (781) 306-8630

Posted: 3 December 2007

BIPOLAR STUDY

Study Location: Manhattan and Brooklyn, NY

Age: 18 - 65

If you have been diagnosed with Bipolar I Disorder and are currently feeling depressed, you may qualify for a study being conducted by the Social Psychiatry Research Institute (SPRI) of an investigational medication for Bipolar I Disorder.  Eligible participants must currently be taking a mood stabilizer.  The purpose of this study is to evaluate the effectiveness of an investigational medication when taken in combination with a mood stabilizer.  Patients may not be currently abusing or dependent on alcohol or illicit drugs.  Study participants will attend regular visits over 10 weeks and receive study medication and medical evaluations at no cost.  Health insurance is not required.  If interested in this study, you can apply online at www.spristudy.com, email us at studyinfo@spristudy.com, or call 1-888-345-7774.

Posted: 28 November 2007

Rewards Study

Have you been told that you have: MANIA, MANIC-DEPRESSION, or BIPOLAR DISORDER?

The University of Miami is conducting a study locally to look at how moods relate to thinking. The study involves an interview about mood changes and different computer tasks and games. The purpose of this study is to understand how people with and without bipolar disorder think about potential rewards. Participants will be paid $25 per hour.

To learn more, please contact: The Rewards Study at 305-284-1587.

Posted: 16 October 2007

Acute Pharmacotherapy of Late-Life Mania- Bipolar Research Study

With aging, many people with bipolar disorder or manic-depression continue to experience mood swings.  Some people develop these symptoms for the first time.  Although effective treatments exist, these problems may remain undiagnosed and untreated or under-treated.

The Weill Cornell Institute of Geriatric Psychiatry is currently conducting a 9-week research study comparing the benefits and side effects of lithium and valproate (divalproex) in the treatment of late-life bipolar disorder.

Services are available for individuals age 60 and older who are currently experiencing an elevated mood and who meet study eligibility criteria.  This study is being conducted at 8 research sites and sub-sites in the U.S. and Canada.  For a free, confidential bipolar screening or for more information about our Bipolar Treatment Study, please call (914) 997-4331 or 800-NYP-1902. 

Posted: 6 September 2007

Research Study Trying to Improve Depressive Symptoms Quickly

Several medications are effective for treating depression; however, they take weeks or months to achieve their full effects.   NIMH (the National Institute of Mental Health) is studying whether a drug can cause a rapid antidepressant effect in patients with bipolar or unipolar depression.  The study also tries to see if it can sustain the results with another medication in certain patients.  Understanding how this works may help us understand depression and design better antidepressants.  NIMH is seeking people ages 18-65 with depression (unipolar or bipolar) who are:

• Free of other serious medical conditions
• Willing to participate in a minimum of a 12-day inpatient stay

Research medications provided free of charge.   Compensation and transportation reimbursement is provided. 

Atendemos pacientes de habla hispana.

Call: 301-496-5645 (TTY: 1-866-411-1010) or Libby Jolkovsky, M.S. at 301-402-9347 or http://patientinfo.nimh.nih.gov; for other studies: www.clinicaltrials.gov

Do you have bipolar disorder (also known as manic depression)? 

We are studying the genetics of how bipolar is transmitted within families.  We are looking for subjects who have the disorder to do an interview and blood draw.  Compensation provided.  Call 888-820-3395, study coordinator Diana Marta, RN, BSN. 

Bipolar Depression Clinical Trial - Have you been diagnosed with bipolar disorder? 

Do you feel that medications have not helped your depression?  If so, you may qualify for an 8-12 week study for treatment of bipolar depression.  We are looking for adults between the ages of 18 and 75, who are depressed, currently in treatment with an outpatient psychiatrist and are taking a mood stabilizer.  Volunteers will receive free study medication, laboratory tests and will be compensated for their participation.  For more information, please call (410) 502-2334.  Principal Investigator: Jennifer Payne, M.D.

Bipolar Disorder Study - Signs and Symptoms:

Feeling down and depressed?  Lost interest in your normal activities?  Do you have uncontrollable mood swings, trouble sleeping, or difficulty concentrating?  Do you experience highs and lows?  If you or someone you know is experiencing any of these symptoms, you may be suffering from Bipolar Depression (also known as Manic Depression).   Daniel D. Anderson, M.D., is conducting a research study for people with Bipolar Depression.  If you qualify, you may be eligible to participate in a study testing the effectiveness of a research medication for the treatment of Bipolar Depression at no cost to you.  If you would like additional information regarding this study and are between the ages of 18 and 75, please contact Dr. Daniel Anderson at (310) 891-0106.

Treating Depression in Patients with Bipolar Disorder:

GlaxoSmithKline (GSK) is sponsoring clinical research studies to evaluate the effectiveness of a medication for treating depression in patients with bipolar disorder.  This medication is currently approved by the FDA for the maintenance treatment of bipolar disorder; however, less is known about its use for acute treatment of bipolar depression.  Patients are randomly assigned to receive either the medication or a placebo for eight weeks.  If eligible, patients will come to the clinic approximately once a week during the treatment phase of the study, and once more for a follow-up visit after the treatment.  To be eligible, a patient must be at least 18 years old, experiencing depression, and have a diagnosis of bipolar disorder.  There are no costs to the patient for study medication, study visits or study procedures.  Participation is entirely voluntary and patients may withdraw from the study at any time for any reason.  Visit BipolarDepressionStudy.com or Veritasmedicine.com (click bipolar disorder then find clinical trials).

Siblings with Bipolar Disorder:

National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services. Looking for families with two or more siblings with bipolar illness. Diane Kazuba, toll-free, at 1-866-NIH-GENES (1-866-644-4363), or email: kazubad@intra.nimh.nih.gov

Adults with Bipolar Disorder and Depression

There are opportunities to participate in clinical trials exploring the research effects of novel therapeutics compared to placebo for the treatment of depression and bipolar disorder. Several of these trials look at treatment-resistant mood disorders. Volunteers over the age of 18 may be eligible. The studies are conducted at the National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, in Bethesda, Maryland. Atendemos pacientes de hable hispana. Call 301-496-5645 or 1-866-627-6464 (TTY: 1-866-411-1010).

Child and Adolescent Bipolar Disorder Study

The National Institute of Mental Health is seeking boys and girls ages 6 to 17 to participate in a study of bipolar disorder in children and adolescents. The study includes a five-day outpatient assessment and infrequent research follow-up visits over four years at the NIH Clinical Center in Bethesda, MD.
Participants must be:

• In treatment with a psychiatrist for bipolar disorder
• On stable medications for the first 6 weeks of the study
• Able to fill out daily self-rating forms and cooperate with study procedures (including genetics studies, MRI, psychological testing, and others)

A thorough evaluation at NIMH is provided free of charge. Travel and lodging expenses are paid for by NIMH. For more information, call 301-496-5645 (TTY: 1-866-411-1010).

Children and Adolescents with Bipolar Disorder  

The National Institute of Mental Health is conducting a study for treatment-resistant bipolar disorder.

Participants will receive:

• Clinical and psychological assessments (including an inpatient assessment during which children will be withdrawn from medication)
• Treatment with clozapine or placebo
• Brain imaging (no radiation)

Participants must:

• Be between the ages of 8 to 17 with bipolar disorder
• Not have done well on lithium, sodium valproate, carbamazepine, and at least one of the newer neuroleptics, as well as a combination of two of these medications

All procedures are free of cost. Travel expenses are paid for. Call Robinder Bhangoo, M.D., or Ellen Leibenluft, M.D., at (301) 496-8381 or (TTY 1-866-411-1010).

Adolescent Bipolar I Study

Participants are needed for a new adolescent Bipolar I Disorder research study of an atypical antipsychotic investigational medication known as Olanzapine. Teenagers must be between ages 13-17 and be diagnosed with Bipolar I Disorder, currently displaying an acute manic or mixed episode, or displaying the symptoms of Bipolar I Disorder. To learn more about participating in this research study, please visit www.teenmentalhealth.net or call toll free 1-866-874-2516.

Bipolar Depression Research Study

This is a six-month Phase IV study comparing two marketed medications in the treatment of bipolar depression. If you have been diagnosed with Bipolar Depression (also called Manic Depression) and are currently depressed with symptoms such as:

• Sadness
• Loss of interest
• Difficulty sleeping
• Lack of energy
• Changes in appetite

You may be eligible to participate in an investigative medication research study comparing two active medications for the treatment of Bipolar depression.
Participants should be 18 to 60 years old, currently depressed, have experienced at least one manic episode in their lifetime, and be in reasonably good health. Participants will have to undergo blood work, urine drug screening and EKG.
Study related tests and evaluation provided at no cost. $20 per visit provided for travel expenses.
Call (888) 317-6262 for more information.

Collaborative Genomic Study of Bipolar Disorder (Non-Treatment Study)

John Rice, Ph.D., at Washington University School of Medicine in St. Louis, in collaboration with 10 other sites across the United States, is conducting a study in an attempt to identify environmental and genetic markers that may be responsible for Bipolar 1 Disorder. A certificate of Confidentiality has been received from the federal government that ensures that all information will be strictly confidential. Data will be assigned a code number and the master list linking the code number and your identity will be kept separate from the research data. This is not a clinical drug-trial or treatment study. Participation will include:

• A confidential personal interview and family history interview
• Small blood sample for the genetic analysis phase of the research study
• Monetary compensation for the time and effort will be provided

If you are at least 18 years old and have a diagnosis of Bipolar 1 (severe form mania), you may be eligible to participate in our research. Participants who live to far from the School of Medicine may be interviewed by telephone. Blood samples may be drawn by local physicians and mailed back to our site if a personal visit from our staff is not possible.
Contact: Caroline E. Drain, M.H.S., Program Manager, Washington School of Medicine, Dept. of Psychiatry, 4625 Lindell Ave., Suite 200, St. Louis, MO 63108
Telephone: (314) 286-1345 or 1-866-289-1378 (toll free). Fax: (314) 454-0432
Email: drainc@msnotes.wustl.edu Web site: http://zork.wustl.edu/bipolar

Recurrent, Early Onset of Depression

NIMH-funded multi-site study of recurrent, early onset depression is looking for families with bipolar illness. The first major depression must have occurred before age 30 in one sibling and before age 40 in the other.

• University of Iowa: Sandra Boutelle, 1-877-578-8845 (toll-free) or 1-319-353-4347, email: boutelle@blue.weeg.uiowa.edu
• University of Pennsylvania: Kathleen Murphy-Eberenz, 1-877-407-9529 (toll-free) or 1-215-746-5153, email: kme@mail.med.upenn.edu
• University of Pittsburgh: Wendy Zubenko, 1-877-485-7568 (toll-free) or 1-412-246-6530, email: wzubenko+@pitt.edu

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