Celexa® (citalopram)
Brand name:
Celexa®
Generic
name: citalopram (sye
TAL oh pram)
Medication
class: Selective serotonin reuptake inhibitor (SSRI) antidepressant
All FDA black box
warnings are at the end of this fact sheet. Please review
before taking this medication.
What
is Celexa® and what does it treat?
Citalopram
is an antidepressant medication that works in the brain. It is
approved for the treatment of major depressive disorder (MDD).
Symptoms
of depression include:
-
Depressed
mood - feeling sad, empty, or tearful
-
Feeling
worthless, guilty, hopeless, and helpless
-
Loss
of interest or pleasure in your usual activities
-
Sleep
and eat more or less than usual (for most people it is less)
-
Low
energy, trouble concentrating, or thoughts of death (suicidal
thinking)
-
Psychomotor
agitation (‘nervous energy’)
-
Psychomotor
retardation (feeling like you are moving and thinking in slow
motion)
-
Suicidal
thoughts or behaviors
What
is the most important information I should know about Celexa®?
Do
not stop taking citalopram even when you feel better. Only your healthcare provider can
determine the length of treatment that is right for you.
Missing
doses of citalopram may increase your risk for relapse in your symptoms.
Stopping citalopram abruptly
may result in one or more of the following withdrawal symptoms:
irritability, nausea, feeling dizzy, vomiting, nightmares, headache,
and/or paresthesias (prickling, tingling sensation on the skin).
Depression
is also a part of bipolar illness. People with bipolar disorder who
take antidepressants may be at risk for "switching" from
depression into mania. Symptoms of mania include "high" or
irritable mood, very high self esteem, decreased need for sleep,
pressure to keep talking, racing thoughts, being easily distracted,
frequently involved in activities with a large risk for bad
consequences (for example, excessive buying sprees).
Are
there specific concerns about Celexa® and
pregnancy?
If
you are planning on becoming pregnant, notify your healthcare
provider to best manage your medications. People living with MDD who
wish to become pregnant face important decisions. Untreated MDD has
risks to the fetus, as well as the mother. It is important to
discuss the risks and benefits of treatment with your doctor and
caregivers.
For
mothers who have taken SSRIs during their pregnancy, there appears to
be less than a 1% chance of infants developing persistent pulmonary
hypertension. This is a potentially fatal condition that is
associated with use of the antidepressant in the second half of
pregnancy. However, women who discontinued antidepressant therapy
were five times more likely to have a depression relapse than those
who continued their antidepressant. If you are pregnant, please
discuss the risks and benefits of antidepressant use with your
healthcare provider.
Caution
is advised with breastfeeding since citalopram does
pass into breast milk.
What
should I discuss with my healthcare provider before taking Celexa®?
-
Symptoms
of your condition that bother you the most
-
If
you have thoughts of suicide or harming yourself
-
Medications
you have taken in the past for your condition, whether they were
effective or caused any adverse effects
-
If
you experience side effects from your medications, discuss them with
your provider. Some side effects may pass with time, but others may
require changes in the medication.
-
Any
other psychiatric or medical problems you have, including a history
of bipolar disorder
-
All
other medications you are currently taking (including over the
counter products, herbal and nutritional supplements) and any
medication allergies you have
-
Other
non-medication treatment you are receiving, such as talk therapy or
substance abuse treatment. Your provider can explain how these
different treatments work with the medication.
-
If
you are pregnant, plan to become pregnant, or are breast-feeding
-
If
you drink alcohol or use drugs
How
should I take Celexa®?
Citalopram is
usually taken 1 time per day with or without food.
Typically
patients begin at a low dose of medicine and the dose is increased
slowly over several weeks.
The
dose usually ranges from 20 mg to 40 mg once daily. For patients
older than 60 years, the maximum recommended dose is 20 mg once
daily. Only
your healthcare provider can determine the correct dose for you.
The
liquid should be measured with a dosing spoon or oral syringe which
you can get from your pharmacy.
Consider
using a calendar, pillbox, alarm clock, or cell to help you remember
to take your medication. You may also ask a family member or friend
to remind you or check in with you to be sure you are taking your
medication.
What
happens if I miss a dose of Celexa®?
If
you miss a dose of citalopram,
take it as soon as you remember, unless it is closer to the time of
your next dose. Discuss this with your healthcare provider. Do not
double your next dose or take more than what is prescribed.
What
should I avoid while taking Celexa®?
Avoid
drinking alcohol or using illegal drugs while you are taking
antidepressant medications. They may decrease the benefits (e.g., worsen your condition) and
increase adverse effects (e.g., sedation) of the medication.
What
happens if I overdose with Celexa®?
If
an overdose occurs, call your doctor or 911. You may need urgent
medical care. You may also contact the poison control center at
1-800-222-1222.
A
specific treatment to reverse the effects of citalopram does not exist.
What
are the possible side effects of Celexa®?
Common
Side Effects
-
Headache,
nausea, diarrhea, dry mouth, increased sweating
-
Feeling
nervous, restless, fatigued, sleepy or having trouble sleeping
(insomnia)
These
will often improve over the first week or two as you continue to take
the medication.
Sexual
side effects, such as problems with orgasm or ejaculatory delay often
do not diminish over time.
Rare
Side Effects
Increased
bleeding (e.g., gums may bleed more easily), low sodium blood levels
(signs of low sodium levels may include headache, weakness,
difficulty concentrating and remembering), teeth grinding
Serious
Side Effects
Seizure
Abnormal
heart rhythm
-
Citalopram
at doses > 40 mg per day could potentially cause a dangerous
abnormality in the electrical activity of the heart. The
abnormality is called QT prolongation. Citalopram use is
discouraged in patients with congenital long QT syndrome. Patients
with low levels of potassium and magnesium in the blood are also at
increased risk.
-
If
you are currently taking citalopram at a dose greater than 40 mg per
day, talk to your healthcare professional. Seek immediate care if
you experience an irregular heartbeat, shortness of breath, dizzy,
or fainting while taking citalopram. If you are taking citalopram,
your healthcare professional may occasionally order an
electrocardiogram (ECG, EKG) to monitor your heart rate and rhythm.
Your healthcare provider may also order tests to check levels of
potassium and magnesium in your blood.
Are
there any risks of taking Celexa® for long periods of time?
To
date, there are no known problems associated with long term use of
citalopram. It is a safe and effective medication when used as
directed.
What
other medications may interact with Celexa®?
Citalopram
should not be taken with or within 2 weeks of taking monoamine
oxidase inhibitors (MAOIs). These include phenelzine (Nardil®),
tranylcypromine (Parnate®),
isocarboxazid (Marplan®),
rasagiline (Azilect®),
and selegeline (Emsam®).
Although
rare, there is an increased risk of serotonin syndrome when
citalopram is used with other medications that increase serotonin,
such as other antidepressants, migraine medications called “triptans”
(e.g., Imitrex®),
some pain medications (e.g., tramadol (Ultram®)),
and the antibiotic linezolid (Zyvox®).
Citalopram
may increase the effects of other medications that can cause bleeding (e.g.,
ibuprofen (Advil®,
Motrin®),
and warfarin (Coumadin®)
and aspirin).
Increased
risk of QT prolongation when used with:
-
Certain
antiarrhythmics: quinidine (Quinidex Extentabs®,
Quinaglute®,
Quinalan®),
procainamide (Procanbid®,
Pronestyl®,
Pronestyl-SR®),
amiodarone (Cordarone®,
Pacerone®),
sotalol (Betapace, Sorine)
-
Certain
antipsychotics: chlorpromazine (Thorazine), thioridazine (Mellaril))
-
Certain
antibiotics: gatifloxacin (Tequin®),
moxifloxacin (Avelox®)
-
Methadone
How
long does it take for Celexa® to
work?
Sleep,
energy, or appetite may show some improvement within the first 1-2
weeks. Improvement in these physical symptoms can be an important
early signal that the medication is working. Depressed mood and lack
of interest in activities may need up to 6-8 weeks to fully improve.
Provided
by the College of Psychiatric and Neurologic Pharmacists
(January
2013)
Summary
of Black Box Warning:
Suicidal
Thoughts or Actions in Children and Adults
-
Depression
and certain other psychiatric disorders are themselves associated
with increases in the risk of suicide.
-
Patients
with major depressive disorder (MDD), both adult and pediatric, may
experience worsening of their depression and/or the emergence of
suicidal ideation and behavior (suicidality) or unusual changes in
behavior, whether or not they are taking antidepressant medications.
This risk may persist until significant remission occurs.
-
In
short-term studies, antidepressants increased the risk of
suicidality in children, adolescents, and young adults when compared
to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants
compared to placebo in adults beyond age 24. Adults age 65 and
older taking antidepressants have a decreased risk of suicidality.
-
Patients,
their families, and caregivers should be alert to the emergence of
anxiety, restlessness, irritability, aggressiveness and insomnia.
If these symptoms emerge, they should be reported to the patient’s
prescriber or healthcare professional.
-
All
patients being treated with antidepressants for any indication
should watch for and notify their healthcare provider for worsening
symptoms, suicidality and unusual changes in behavior, especially
during the first few months of treatment.
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