National Alliance on Mental Illness
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Generic name: vilazodone (vil AZ oh done)
Medication class: Selective serotonin reuptake inhibitor/5HT1A partial agonist
All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.
What is Viibyrd® and what does it treat?
Vilazodone is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD).
Symptoms of depression include:
What is the most important information I should know about Viibyrd®?
Do not stop taking vilazodone, even when you feel better. Only your healthcare provider can determine the length of treatment that is right for you.
Missing doses of vilazodone may increase your risk for relapse in your symptoms.
Stopping vilazodone abruptly may result in one or more of the following withdrawal symptoms: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).
Depression is also a part of bipolar illness. People with bipolar disorder who take antidepressants may be at risk for "switching" from depression into mania. Symptoms of mania include "high" or irritable mood, very high self esteem, decreased need for sleep, pressure to keep talking, racing thoughts, being easily distracted, frequently involved in activities with a large risk for bad consequences (for example, excessive buying sprees).
Are there specific concerns about Viibyrd® and pregnancy?
If you are planning on becoming pregnant, notify your healthcare provider to best manage your medications. People living with MDD who wish to become pregnant face important decisions. Untreated MDD has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.
Caution is advised with breastfeeding since vilazodone does pass into breast milk.
What should I discuss with my healthcare provider before taking Viibyrd®?
How should I take Viibyrd®?
Vilazodone is usually taken 1 time per day with food or milk.
Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.
The dose usually ranges from 10 mg to 40 mg. Only your healthcare provider can determine the correct dose for you.
Consider using a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or friend to remind you or check in with you to be sure you are taking your medication.
What happens if I miss a dose of Viibyrd®?
If you miss a dose of vilazodone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
What should I avoid while taking Viibyrd®?
Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications. They may decrease the benefits (e.g., worsen your condition) and increase adverse effects (e.g., sedation) of the medication.
What happens if I overdose with Viibyrd®?
If an overdose occurs, call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.
A specific treatment to reverse the effects of vilazodone does not exist.
What are the possible side effects of Viibyrd®?
Common Side Effects
Diarrhea, nausea, vomiting, dry mouth, dizziness, insomnia
Rare Side Effects
Night sweats, decreased appetite, migraine headaches, sleepiness, tremor, blurry vision, dry eyes, abnormal dreams, agitation, restlessness, increased urination, sexual dysfunction
Serious Side Effects
Palpitations, irregular heartbeat
Are there any risks of taking Viibyrd® for long periods of time?
To date, there are no known problems associated with long term use of vilazodone. It is a safe and effective medication when used as directed.
What other medications may interact with Viibyrd®?
Vilazodone should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors (MAOIs). These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azalect®) and selegeline (Emsam®).
Although rare, there is an increased risk of serotonin syndrome when vilazodone is used with other medications that increase serotonin, such as other antidepressants, migraine medications called ‚Äútriptans‚ÄĚ (e.g., Imitrex®), some pain medications (e.g., tramadol (Ultram®), and the antibiotic linezolid (Zyvox®).
Vilazodone may increase the effects of other medications that can cause bleeding (e.g., ibuprofen (Advil®, Motrin®), warfarin (Coumadin®) and aspirin).
The following medications may increase the levels and effects of vilazodone:
The following medications may decrease the levels and effects of vilazodone: carbamezapine (Tegretol®), oxcarbazepine (Trileptal®), rifampin (Rifadin®), phenytoin (Dilantin®), and phenobarbital
How long does it take for Viibyrd® to work?
Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
Provided by the College of Psychiatric and Neurologic Pharmacists
Summary of Black Box Warnings
Suicidal Thoughts or Actions in Children and Adults