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Depression Research Studies

Depression Treatment Not Working?

KU Wichita Clinical Trial Unit researchers are looking for adults (ages 18-65) who are suffering from depression to participate in a research study offering a cutting edge treatment.  To participate the current depressive episode must last at lasted eight weeks.

Those who qualify will receive:
• Study related mental health assessments
• Physical exams
• Lab Assessments
• Study Medication

To see if you qualify, call 316-293-1833.

Trial Investigators: Dr. Matthew Macaluso and Dr. Sheldon Preskorn

Depression Treatment Options: What Matters Most?

Date: September 2, 2014

Have you ever suffered from depression? Voice your opinions to help improve the quality of depression care for patients across the United States.

We are researchers from Dartmouth College conducting a national survey to better understand what is important to patients when making decisions about depression treatment. Responses are anonymous and confidential. For more information or to take the survey, please go to:

Major Depressive Disorder Research Study

Date: August 26, 2014

If you are an adult with depression and are still experiencing symptoms while taking an antidepressant, consider participating in the MOSIAC clinical research study.  Visit the website to learn more and see if you may qualify.

For more information, please contact the Treatment Research Center at Rush University Medical Center in Chicago: 312-942-6597

Does Your Child Suffer From Depression?

We are looking for adolescents age 12-17 who are suffering from Major Depressive Disorder (MDD) to participate in a new Clinical Research Trial.

Purpose: To find out if an investigational drug is safe and to learn if it works for adolescents who have major depressive disorder (MDD).


Kennedy Krieger Institute 443-923-3850

716 N. Broadway Baltimore, MD 21205

Robert Findling, M.D., M.B.A., Principal Investigator

NA_00086408, (NCT01878292)

Have you tried antidepressants and are you still struggling with depression?

Date: January 13, 2014

If so, please contact us about our 13-week research trial of an investigational, non-medication treatment for depression.

You may be able to participate if:

  • You are 18 to 70 years of age
  • Antidepressants have not fully relieved your depression symptoms or if you are unable to tolerate the side effects of your antidepressant

Qualified participants receive:

  • Study-related care and study treatment at no cost
  • Compensation for time and travel

To learn more, please visit:

Depression and Anxiety Make Ghosts of Us All

Date: January 10, 2014

Childhood depression and anxiety greatly impact the lives of sufferers, taking away their ability to enjoy their childhood and making them a ghost or shadow of their former selves. We want to change this. We’re conducting ADVANCE – a clinical research study looking at how an investigational treatment called Lu AA21004 is processed in the body over time in children aged 7 to 17 years (inclusively) with depression or anxiety. Study–related treatments and procedures will be provided at no cost to you.

Please contact the study coordinator at 443-923-3850 to learn more.

Principal Investigator: Robert L. Findling, M.D. M.B.A.

Feeling depressed?

Date: September 16, 2013

It may be time to consider your options.

A Clinical Research Study for an investigational medicine is enrolling people who

  • Are currently taking an antidepressant but still need additional relief


  • Are not taking antidepressant medications but think they may have depression

What is involved?

  • Qualified participants will receive study medication and study-related medical care at no cost.
  • Receive study related care by doctors who are currently treating depression
  • Take an active role in your own healthcare

Compensation for time and travel may be provided

Minimum Qualifications

  • An adult between 18 and 65 years old
  • Currently experiencing symptoms of depression
  • Willing to take the study medication along with a prescribed antidepressant medication

The study doctor can tell you if you meet all the study eligibility requirements.

Sad all the time. No energy. Feeling worthless. Trouble sleeping. Can’t focus. If you are experiencing these symptoms, this study may be right for you.

To learn more and find out if you may qualify, please visit http://

Feeling depressed?

Take part in a research study of an investigational medicine at no cost.

To qualify you must be :

  • Ages 19 to 65. </ li>
  • Willing to take study medication and antidepressant.

For more information contact Premier Psychiatric Research Institute at (402) 476-6060 (Option 4) and 

Date: March 5, 2013

New Study Seeks Answers to Help People with Psychotic Depression

Most of us have heard of depression, but few people may know about a type of depression that appears along with psychosis (or a loss of touch with reality). Referred to as psychotic major depression (PMD), it’s a surprisingly common mental disorder that affects more than one in 100 individuals. If you or someone in your life has depressed feelings along with ideas or ways of thinking that are not true and/or see or hear things that aren’t there – it may be PMD. With PMD for example, people may hear voices telling them that they don’t deserve to live. There is a high risk of suicide for individuals with PMD so it’s critical to seek help and get treated immediately. [Note: If you have thoughts of suicide or harming yourself or others, immediately call 911 or go to your nearest hospital emergency room. You also may call a confidential suicide hotline from anywhere in the United States, 24 hours a day, seven days a week at 1-800-273-TALK (8255).]

People with PMD can and do get better with treatment. A combination of antidepressant and antipsychotic medication is an effective medication treatment.

In a new study called STOP PD II, researchers are working to understand how long people need to stay on an antipsychotic medication to prevent new episodes of psychosis after recovering from their initial symptoms. Individuals in this study will first receive a combination of an antipsychotic medication and an antidepressant medication for up to 20 weeks. They may begin in an inpatient or outpatient setting. Individuals who are nearly or fully better after up to 20 weeks will be invited to participate in a second phase of the study that lasts for up to 36 weeks.

To be eligible for the study, individuals must be 18 to 85 years old, experiencing symptoms of depression with psychosis, and not be pregnant. Study participants receive medication and medical care at no cost.

For more information about voluntary participation in this study call: Joelle M. Scanlon, PhD, at 412-246-6012

Date: January 24, 2013

Feelings in the Family Study

Are you:

  • A mother of one or more children between the ages of 6 to 12 years?
  • Experiencing feelings of depression?

Researchers in the Department of Child and Adolescent Studies at Cal State Fullerton are conducting a study to better understand how family members get along when a parent is experiencing some depressive feelings.

Participation includes a phone interview and questionnaires by mail. Families are compensated $25 for their time.

For more information, contact Marian Howland at (657) 278-1088 or

Date: January 8, 2013

Are you a woman between the ages of 45 and 55 and entering the transition to menopause?

The PERT (Perimenopausal Estrogen Replacement Therapy) Study is a clinical research study investigating cardiovascular health and psychological well-being during the menopause transition.

The PERT Study is enrolling two groups of women:

  • Women who have had more than one experience with depressive episodes in the past but who are currently not suffering from depression; and
  • Women who have never suffered from depression.

Eligible women will be randomly assigned (i.e., by chance) to either transdermal ERT (a skin patch containing 17b-estradiol) or placebo (a skin patch containing an inert substance). Participants will be involved in the study for 12-13 months with an optional 12 month follow-up period. Approximately 10 visits will be necessary over the initial 12-month period.

You may be eligible to participate if you are:

  • Living in North Carolina
  • Between the ages of 45 and 55
  • Medically healthy
  • Experiencing symptoms of the transition to menopause, such as irregular or absent cycles, hot flashes, etc.

What will you receive if you participate?

  • $1,325 for completing the full 12-month enrollment protocol and an additional $100 for the 12-month follow-up period.
  • 1 to 2 free screening mammograms
  • Free gynecological exam
  • Free medical screenings, including monitoring of glucose and lipid levels
  • Educational materials regarding health and well-being

For more information, click here to visit our study website or please call:  (919) 972-7495

Date: Nov. 2, 2012

Is your major depressive disorder (MDD) a daily challenge?

Have you tried medications for your depression in the past which didn’t seem to help?
Are you currently taking an antidepressant but still feel low, tired, and depressed?

The Pursuit study is currently being conducted in your area to determine how safe and effective an investigational medication is for treating MDD.

We are looking for patients who:

  • Between the ages of 18-70, inclusive
  • have been diagnosed with MDD
  • have severe depressive symptoms but are not hospitalized
  • have tried at least three different antidepressants to treat their MDD over their lifetime which didn’t seem to help
  • are currently taking one or more antidepressants

The study will last for 20 weeks and will require approximately 20 visits to the study center so that study doctors and nurses can perform various tests and monitor how the drug affects you. Qualified participants will receive all study-related office visits, medical examinations, and investigational medication at no cost. Additionally, the cost of your currently prescribed medications for depression may be supplemented during your study participation.

For more information, click here to visit our study website or please call:  1-888-643-2056

TRIADE – Antidepressant Clinical Trial

Date: Oct. 6, 2011

The TRIADE trial is designed to assess amitifadine, a new drug being developed as a possible new antidepressant intended to reduce many of the side effects associated with typical antidepressant medications.

Who Can Participate in TRIADE?

  • People who have major depressive disorder
  • People who have not responded adequately to a single course of a previous antidepressant medication (SSRIs or SNRIs)

What is amitifadine?

  • Amitifadine is an investigational medication to treat depression that acts on three chemicals in the brain

What can you expect if you participate in TRIADE?

  • TRIADE is a 13 week trial
  • The purpose of the study is to assess the safety and effectiveness of the investigational medication
  • Some participants will be given amitifadine, while some will get a standard treatment and some will be given a pill with no medication (a placebo) for comparison

The trial will be conducted at approximately 30 centers throughout the U.S., and is expected to include approximately 318 individuals.

For full enrollment criteria and to locate a center near you, please call 1 (888) 414-1808 or visit

TRIADE is sponsored by Euthymics® Bioscience, Inc., maker of amitifadine.


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