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Zyprexa® (olanzapine)

Brand names:

Zyprexa®

– Tablets: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg

  • Orally disintegrating tablets: 5 mg, 10 mg, 15 mg, 20 mg

  • Injection (immediate release): 10 mg vials

Zyprexa Relprevv®

  • Injection (extended release): 150 mg, 210 mg, 300 mg, 405 mg

Generic name: olanzapine (oh LAN za peen)

Medication class: Second generation antipsychotic (SGA), atypical antipsychotic

All FDA black box warnings are at the end of this fact sheet.  Please review before taking this medication.

What is Zyprexa® and what does it treat?

Olanzapine is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Olanzapine rebalances dopamine and serotonin to improve thinking, mood, and behavior.

Symptoms of schizophrenia include:

  • Hallucinations - imagined voices or images that seem real

  • Delusions - beliefs that are not true (e.g., other people are reading your thoughts)

  • Disorganized thinking or trouble organizing your thoughts and making sense

  • Little desire to be around other people

  • Trouble speaking clearly

  • Lack of motivation

Olanzapine may help some or all of these symptoms.

Olanzapine is also FDA approved for the following indications:

  • Acute treatment of manic or mixed episodes of bipolar disorder

  • Maintenance (long-term) treatment of bipolar disorder

  • Acute treatment of agitation in schizophrenia and bipolar disorder

This medication sheet will focus primarily on schizophrenia. You can find more information about bipolar disorder and depression at http://www.nami.org/Template.cfm?Section=By_Illness.

What is the most important information I should know about Zyprexa®?

Schizophrenia requires long-term treatment. Do not stop taking olanzapine, even when you feel better.

Only your healthcare provider can determine the length of olanzapine treatment that is right for you.

Missing doses of olanzapine may increase your risk for a relapse in your symptoms.

Do not stop taking olanzapine or change your dose without talking to with your healthcare provider first.

For olanzapine to work properly, it should be taken everyday as ordered by your healthcare provider.

Are there specific concerns about Zyprexa® and pregnancy?

If you are planning on becoming pregnant, notify your healthcare provider to best manage your medications. People living with schizophrenia who wish to become pregnant face important decisions. This is a complex decision since untreated schizophrenia has risks to the fetus, as well as the mother. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

Caution is advised with breastfeeding since olanzapine does pass into breast milk. It is recommended that women receiving olanzapine should not breast-feed.

What should I discuss with my healthcare provider before taking Zyprexa®?

  • Symptoms of your condition that bother you the most

  • If you have thoughts of suicide or harming yourself

  • Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects

  • If you ever had muscle stiffness, shaking, tardive dyskinesia, neuroleptic malignant syndrome, or weight gain caused by a medication

  • If you experience side effects from your medications, discuss them with your provider. Some side effects may pass with time, but others may require changes in the medication.

  • Any psychiatric or medical problems you have, such as heart rhythm problems, long QT syndrome, heart attacks, diabetes, high cholesterol, or seizures

  • If you have a family history of diabetes or heart disease

  • All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have

  • Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication.

  • If you are pregnant, plan to become pregnant, or are breast-feeding

  • If you smoke, drink alcohol, or use illegal drugs

How should I take Zyprexa®?

Olanzapine tablets are usually taken 1 time per day with or without food.

Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

The oral dose usually ranges from 5 mg to 20 mg. Only your healthcare provider can determine the correct dose for you.

Olanzapine orally disintegrating tablets must remain in their original packaging. Open the package with clean dry hands before each dose. Do not try to put tablets in a pillbox if you take the orally disintegrating tablets.

Olanzapine orally disintegrating tablets will dissolve in your mouth within seconds and can be swallowed with or without liquid.

Use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication.  You may also ask a family member a friend to remind you or check in with you to be sure you are taking your medication.

The long-acting injection form of olanzapine is administered every 2 to 4 weeks. Your healthcare provider will administer these injections and keep you in a setting where you can be observed for at least 3 hours after each injection.

What happens if I miss a dose of Zyprexa®?

If you miss a dose of olanzapine, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.

What should I avoid while taking Zyprexa®?

Avoid drinking alcohol or using illegal drugs while you are taking olanzapine. They may decrease the benefits (e.g. worsen your confusion) and increase adverse effects (e.g. sedation) of the medication.

What happens if I overdose with Zyprexa®?

If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

A specific treatment to reverse the effects of olanzapine does not exist.

What are possible side effects of Zyprexa®?

Common Side Effects

Low blood pressure, upset stomach, constipation, dry mouth

Feeling dizzy, drowsy or restless

Rare Side Effects

Seizures, changes in body temperature, impaired sexual function

Olanzapine may increase the blood levels of a hormone called prolactin. Side effects of increased prolactin levels include females losing their period, production of breast milk and males losing their sex drive or possibly experiencing erectile problems. Long term (months or years) of elevated prolactin can lead to osteoporosis, or increased risk of bone fractures.

Serious Side Effects

Some people may develop muscle related side effects while taking olanzapine. The technical terms for these are “extrapyramidal effects” (EPS) and “tardive dyskinesia” (TD). Symptoms of EPS include restlessness, tremor, and stiffness. TD symptoms include slow or jerky movements that one cannot control, often starting in the mouth with tongue rolling or chewing movements.

Second generation antipsychotics (SGAs) increase the risk of weight gain, high blood sugar, and high cholesterol. This is also known as metabolic syndrome. Your healthcare provider may ask you for a blood sample to check your cholesterol, blood sugar, and hemoglobin A1c (a measure of blood sugar over time) while you take this medication.

SGAs have been linked with higher risk of death, strokes, and transient ischemic attacks (TIAs) in elderly people with behavior problems due to dementia.

All antipsychotics have been associated with the risk of sudden cardiac death due to an arrhythmia (irregular heart beat). To minimize this risk, antipsychotic medications should be used in the smallest effective dose when the benefits outweigh the risks. Your doctor may order an EKG to monitor for irregular heart beat.

Neuroleptic malignant syndrome is a rare, life threatening adverse effect of antipsychotics which occurs in <1% of patients. Symptoms include confusion, fever, extreme muscle stiffness, and sweating. If any of these symptoms occur, contact your healthcare provider immediately.

Are there any risks of taking Zyprexa® for long periods of time?

Tardive dyskinesia (TD) is a side effect that develops with prolonged use of antipsychotics. Medications such as olanzapine have been shown to have a lower risk of TD compared to older antipsychotics, such as Haldol® (haloperidol).] If you develop symptoms of TD, such as grimacing, sucking, and smacking of lips, or other movements that you cannot control, contact your healthcare provider immediately. All patients taking either first or second generation antipsychotics should have an Abnormal Involuntary Movement Scale (AIMS) completed regularly by their healthcare provider to monitor for TD.

Second generation antipsychotics (SGAs) increase the risk of diabetes, weight gain, high cholesterol, and high triglycerides. (See “Serious Side Effects” section for monitoring recommendations.)

What other medications may interact with Zyprexa®?

Olanzapine may block the effects of agents used to treat Parkinson’s disease such as levodopa/carbidopa (Sinemet®), bromocriptine, pramipexole (Mirapex®), ropinirole (Requip®), and others.

Medications used to lower blood pressure may increase this effect. Propranolol (Inderal®) is an example of this type of medication.

Sedative medications, such as lorazepam (Ativan®) and diazepam (Valium®) may increase the risk of dizziness or sleepiness when used in combination with olanzapine. This risk is increased when these medications are given as an injection.

The following medications may increase the levels and effects of olanzapine: ciprofloxacin (Cipro®) and fluvoxamine (Luvox®)

Carbamazepine (Tegretol®) may decrease the levels and effects of olanzapine.

Cigarette smoke can decrease levels of olanzapine. Let your healthcare provider know if you start or stop smoking cigarettes. Nicotine patches do not impact olanzapine levels.

How long does it take for Zyprexa® to work?

It is very important to tell your doctor how you feel things are going during the first few weeks after you start taking olanzapine. It will probably take several weeks to see big enough changes in your symptoms to decide if olanzapine is the right medication for you.

Antipsychotic treatment is generally needed lifelong for persons with schizophrenia. Your doctor can best discuss the duration of treatment you need based on your symptoms and illness.

  • Hallucinations, disorganized thinking, and delusions may improve in the first 1-2 weeks

  • Sometimes these symptoms do not completely go away

  • Motivation and desire to be around other people can take at least 1-2 weeks to improve

  • Symptoms continue to get better the longer you take olanzapine

  • It may take 2-3 months before you get the full benefit of olanzapine 

Provided by

College of Psychiatric and Neurologic Pharmacists

(January 2013)

Summary of FDA Black Box Warnings

Increased Mortality in Elderly Patients with Dementia Related Psychosis

  • Both first generation (typical) and second generation (atypical) antipsychotics are associated with an increased risk of mortality in elderly patients when used for dementia related psychosis.

  • Although there were multiple causes of death in studies, most deaths appeared to be due to cardiovascular causes (e.g. sudden cardiac death) or infection (e.g. pneumonia).

  • Antipsychotics are not indicated for the treatment of dementia-related psychosis.

Suicidal Thoughts or Actions in Children and Adults

  • Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.

  • Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking medications. This risk may persist until significant remission occurs.

  • Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional.

  • All patients being treated with this medication for depression should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.


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