A study appearing in August 18, 2004 issue of the Journal of the American Medical Association (JAMA) found that combining Prozac with Cognitive Behavioral Therapy (CBT) is the most effective treatment for adolescent depression. More specifically, this large multi-site, NIMH funded study found that 71% of youth with depression and receiving Prozac and CBT showed substantial improvement, while 61% of those taking Prozac alone showed improvement, 43% of those receiving CBT alone showed improvement and 35% of those receiving placebo (sugar pills) improved.
The study also showed that there are risks for a small subset of youth taking Prozac related to harm to self or others at the same time that the medication combined with CBT and used alone leads to significant improvement in the majority of youth. This shows the critical need for close monitoring of youth taking medication as part of sound clinical practice and the need for increased research on youth depression and other mental illnesses.
Read the full report in the Journal of the American Medical Association.