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Researchers Identify Pathway Connecting Chronic Stress, Inflammation and Mood Disorders

May 22 2020
Researchers are beginning to understand exactly how chronic stress plays a role in the development of conditions like anxiety and depression. Past studies have connected chronic stress to inflammation in the brain. And now, using a specialized mouse model, researchers have demonstrated that stress only leads to behavior change, like social withdrawal and memory deficits, when receptors for the inflammatory compound Interleukin-1 are active in the hippocampus. If future studies replicate this pathway in humans, it may lead to new, specialized treatment options. To learn more, see the study in Molecular Psychiatry.