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Randomized Controlled Trial finds NAMI Basics Effective for Caregivers of Children with Mental Health Symptoms

NAMI Basics is a no-cost education program for parents, caregivers and others who provide care for youth experiencing mental health symptoms. For the first time, the effectiveness of NAMI Basics was tested using a randomized controlled study design. Caregivers were randomly assigned to either a 6-week, peer parent-led NAMI Basics course, or an 8-week waitlist. At the end of the study, caregivers participating in the NAMI Basics course showed increased engagement with their child’s symptoms and intentions to seek out services compared with the waitlist group. Participating caregivers also reported decreased intrapersonal and interpersonal distress among their children. To learn more, see the study in Psychiatric Services.

Randomized Clinical Trial Finds Probiotics May Help Support Treatment of Major Depressive Disorder

New research suggests a potentially important role for the microbiome-gut-brain axis in treating individuals with major depressive disorder (MDD). In a randomized controlled trial, 21 patients were given a probiotic supplement in conjunction with antidepressants for one month. Compared to the control group, those given a probiotic showed greater improvement in depressive symptoms and emotional processing based on neural imaging. Further research should continue exploring the benefits of probiotic supplementation for managing symptoms of depression. To learn more, see the study in Translational Psychiatry.

Psychosis Outside the Box: Personal Narratives of Psychosis

Much of the available information about psychosis comes from a medical perspective, which can make those experiencing psychosis feel misunderstood or invalidated by the mental health care system. Two researchers, both diagnosed with schizophrenia, began “Psychosis Outside the Box” to provide an alternative. “Psychosis Outside the Box” is an ongoing project that compiles first-person accounts of psychosis in an online repository. The researchers hope the stories can be shared with other researchers and clinicians to better identify and serve individuals experiencing psychosis, particularly during the early stages when engagement is critical. To learn more, see the article in Psychiatric Services.
 

Psychological Distress Increases Risk of Post-COVID-19 Complications

A study of nearly 55,000 participants found that individuals with psychological distress markers before a COVID-19 diagnosis were nearly 1.5 times more likely to show symptoms of post-COVID-19 conditions (commonly referred to as long COVID). Depression, anxiety, worry about contracting COVID-19, loneliness and stress were associated with complications post-COVID-19 infection and impairment in daily living, even after adjusting for health-related factors. Individuals with two or more types of psychological distress were the most likely to present post-COVID-19 conditions. Future research should explore whether interventions to reduce psychological distress can help prevent or mitigate physical health conditions, such as long COVID. To learn more, see the study in JAMA Psychiatry.
 

Promoting Clozapine in A Community Mental Health Clinic

Despite being effective for treatment-resistant schizophrenia, clozapine is underutilized. To increase prescriptions, a clozapine community clinic with a multidisciplinary team of health practitioners was established in 2015. Providers utilized the best practice alert (BPA) to identify ideal patient candidates for clozapine treatment and since its inception, the number of patients receiving clozapine treatment increased from 57 to 124. Patients received weekly group support, education, telehealth, and access to a centralized clozapine resource toolkit. Intervention programs also evaluated existing attitudes and awareness regarding clozapine and provided education to healthcare providers. To learn more, see the article in Psychiatric Services.
 

Pandemic may be Linked with Inflammatory Brain Markers, Mood Changes

Many people have felt the mental health effects of the COVID-19 pandemic, and new research indicates that even individuals who never contracted the illness may experience stress-related changes in brain function. Researchers used brain imaging and other health metrics to compare “pre-pandemic” and “pandemic” data for individuals who tested negative for SARS-CoV-2 antibodies. Even in these healthy individuals, the data showed elevated levels of inflammatory markers associated with mood issues and fatigue following 2020 lockdown measures. To learn more, see the study in Brain, Behavior, and Immunity, and take a look at NAMI’s Mental Health by the Numbers for additional information on the pandemic’s impact on mental health.

Pandemic Associated with Increased Symptoms Among Individuals with Eating Disorders

A systematic review and meta-analysis examined 13 studies to better understand how the COVID-19 pandemic and subsequent lockdowns influenced the symptoms and treatment plans of individuals with eating disorders (EDs). Selected studies included populations from the U.K., U.S., and other countries. During the pandemic, about 60% of individuals with EDs reported a worsening of symptoms such as binge eating, purging, food restriction, and concerns surrounding food intake, as well as increases in anxiety and depression related to their ED. The researchers also found that individuals with EDs may have difficulties engaging with telehealth – one of the key methods of health care access during the pandemic. To learn more, see the study in the Journal of Eating Disorders.  

Ongoing Improvements to Early Psychosis Research and Treatment

Research has shown that treatment of early psychosis improves clinical outcomes. In 2018, the Early Psychosis Intervention Network (EPINET) was established with the aim of conducting practice-oriented research to develop high quality care for treatment of first-episode psychosis (FEP). Currently, eight regional networks function through a learning health care (LHC) framework with diverse stakeholders, a research hub, and coordinated specialty care (CSC) programs. A national repository has also been created for collaboration in developing evidence-based practices, standardizing data collection, and producing assessments to inform policy. Researchers express interest in expanding access to LHC resources to non-EPINET CSC programs and working with international partners. To learn more, see the article in Psychiatric Services. 

NAMI Provider Education Program Helps in Improving Future Healthcare Professionals’ Competency

NAMI Provider is a no-cost training program designed to help mental health professionals understand the lived experience of mental illness and promote a collaborative model of care. To assess the effectiveness of different delivery methods, 325 medical students were assigned to participate in either a traditional, community-based program (Cohort 1) or an online, active learning program (Cohort 2). Both cohorts showed reduced anxiety interacting with patients with mental illness, decreased stereotyping attitudes, and improved confidence incorporating psychiatry into routine care, with stronger effects among students receiving the online format. The findings highlight the potential benefits of the NAMI Provider program, even when adapted to a virtual learning environment. To learn more, see the article in Medical Education Online.

Mobile Phone-Based Mental Health Interventions Show Positive – but Modest – Results

Mobile phone-based mental health interventions have gained popularity as a potential solution to the cost and access issues of traditional mental health care. A new study analyzed previous research on such interventions, including 145 studies involving 48,000 participants, to determine whether they benefit users as designed. Overall, the study found modest positive results for certain conditions – such as anxiety and depression – but little evidence that mobile-phone based interventions are as effective or more effective than traditional care. More rigorous studies, including a full exploration of potential negative outcomes, are necessary to understand the impact of these interventions. To learn more, see the study in PLOS Digital Health.

NAMI HelpLine is available M-F, 10 a.m. – 10 p.m. ET. Call 800-950-6264,
text “NAMI” to 62640, or email. In a crisis, call or text 988 (24/7).