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Talk therapy has been shown to work for depression, even in people who have not gotten better from medication in the past.6 Therapy can provide tools for dealing with life stressors that medication cannot help. It has also been shown that the effects of therapy can last longer than the effects of medications. Most people do better on both talk therapy and medication than just one alone.2,6
Additionally, there are certain brain stimulation procedures for treatment-resistant depression that are performed by a physician in a clinic. Transcranial magnetic stimulation (TMS) is done when a person is awake while electroconvulsive therapy (ECT) and vagus nerve stimulation (VNS) are done when a person is under sedation.2 These are used when many different medications have failed to help depression symptoms.
Bobbi Jo Loflin, PharmD, January 2020
To view the references for this resource, please visit aapp.org/428343.
©2022 American Association of Psychiatric Pharmacists (AAPP). AAPP makes this document available under the Creative Commons Attribution-NoDerivatives 4.0 International License. Last Updated: January 2016.
This information is being provided as a community outreach effort of the American Association of Psychiatric Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the topic. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The American Association of Psychiatric Pharmacists disclaims any and all liability alleged as a result of the information provided herein.