Learn the common signs of mental illness in adults and adolescents.
Learn more about common mental health conditions that affect millions.
Find Your Local NAMI
Call the NAMI Helpline at
Or text "HelpLine" to 62640
Generic name: buspirone (byoo SPYE rone)
All FDA black box warnings are at the end of this fact sheet. Please review before taking this medication.
Buspirone is in a class of medications called anti-anxiety medications. Buspirone is not related to other anti-anxiety medications, such as benzodiazepines, barbiturates or other sedative/ anxiolytic drugs. It is approved for the treatment of generalized anxiety disorder (GAD).
Generalized Anxiety Disorder (GAD) occurs when a person experiences excessive anxiety or worry for at least six months. Other symptoms include:
Do not drive a car or operate machinery until you know how this medication affects you because you may notice that you feel tired or dizzy.
Alcohol may increase any drowsiness or dizziness when taken with buspirone. You should avoid the use of alcohol while taking buspirone.
It may take 3 to 4 weeks before you start to feel better. Initially you may begin to notice a decrease in irritability and worry. Do not stop taking this medication without talking to your health care provider first. With input from you, your health care provider will assess how long you will need to take the medication.
Unlike other anti-anxiety medications, buspirone has very low abuse potential.
If you are pregnant or planning to become pregnant, notify your health care provider to best manage your medications. People living with anxiety disorders who wish to become pregnant face important decisions. It is important to discuss this with your doctor and caregivers.
Regarding breastfeeding, caution is advised since it is unknown whether buspirone passes into breast milk.
Buspirone should be taken twice a day with or without food.
Your health care provider will determine the dose that is right for you based upon your response.
Use a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also ask a family member or friend to remind you or check in with you to be sure you are taking your medication.
If you miss a dose of buspirone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed.
Avoid drinking large amounts of grapefruit juice while taking buspirone.
Avoid drinking alcohol and using illegal drugs while you are taking buspirone. They may decrease the benefits (e.g., worsen your condition) and increase the adverse effects (e.g., sedation) of the medication.
Avoid drinking large amounts of grapefruit juice while taking buspirone
If an overdose occurs, call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.
A specific treatment to reverse the effects of buspirone does not exist.
Common side effects
Rare/serious side effects
Changes in weight or appetite, fainting, changes in blood pressure, muscle cramps or spasms, and redness or itching of eyes may occur in some instances.
Allergic reaction (difficulty breathing; hives; swelling of your lips, tongue or face); chest pain or an irregular heartbeat; slurred speech; confusion or blurred vision; numbness or tingling in your hands, feet, arms, or legs; or uncontrollable movements of your arms, legs, tongue, or lips.
To date, there are no known problems associated with the long term use of buspirone. It is a safe and effective medication when used as directed.
If you have taken a monoamine oxidase inhibitor (MAOI), such as phenelzine (Nardil®), isocarboxazid (Marplan®), selegiline (Eldepryl®, EMSAM®) or tranylcypromine (Parnate®), within the past 2 weeks, do not take buspirone. The use of buspirone with these agents can cause a dangerous increase in your blood pressure.
The following medications may increase the levels and effects of buspirone:
The following medications may decrease the levels and effects of buspirone:
It may take 3 to 4 weeks of taking buspirone every day before you start to feel better.
Buspirone does not have any black box warnings.
©2022 The American Association of Psychiatric Pharmacists (AAPP) and the National Alliance on Mental Illness (NAMI). AAPP and NAMI make this document available under the Creative Commons Attribution-No Derivatives 4.0 International License. Last Updated: January 2016.
This information is being provided as a community outreach effort of the American Association of Psychiatric Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions. Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The American Association of Psychiatric Pharmacists disclaims any and all liability alleged as a result of the information provided herein.
In a crisis? Call or text 988.