Clonidine (Kapvay and Catapres)

Generic Name: Clonidine (KLON i deen)

Brand Names: Kapvay

  • Tablets: 0.1 mg, 0.2 mg (extended release)

Catapress

  • Tablets: 0.1 mg, 0.2 mg, 0.3 mg (immediate release)

Medication class: Central alpha agonist

What is clonidine and what does it treat?

Clonidine is a prescription medication that is used to treat attention deficit hyperactivity disorder (ADHD) in individuals between 6 and 17 years of age. Clonidine is also used to treat high blood pressure in both children and adults.

Symptoms of ADHD interfere with an individual’s ability to function at school or work or in social settings and include:

  • Inattention (making careless mistakes, losing things necessary for tasks)
  • Hyperactivity (inability to sit still)
  • Impulsivity (interrupting or intruding on others)

A person may have severe inattention without hyperactivity or impulsivity.

Clonidine is used in addition to non-medication treatments to manage ADHD symptoms.

What is the most important information I should know about clonidine?

Although some symptoms may improve within days of starting clonidine, it may take several weeks before you notice the full benefits of the medication.

Are there specific concerns about clonidine and pregnancy?

If you are planning on becoming pregnant, notify your health care provider so that he/she can best manage your medications. People living with ADHD who wish to become pregnant face important decisions. There are no well-controlled studies of clonidine use in pregnant women. Animal studies did not demonstrate evidence of fetal harm. It is important to discuss the risks and benefits of treatment with your doctor and caregivers.

Regarding breastfeeding, caution is advised since clonidine does pass into breast milk.

What should I discuss with my health care provider before taking clonidine?

  • Symptoms of your condition that bother you the most
  • If you have thoughts of suicide or harming yourself
  • If you experience side effects from your medications, discuss them with your provider. Some side effects pass with time, but others may require changes in the medication.
  • Any other psychiatric or medical problems you have, including heart disease
  • All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and any medication allergies you have
  • Other non-medication treatment you are receiving, such as talk therapy or substance abuse treatment. Your provider can explain how these different treatments work with the medication.
  • If you are pregnant, plan to become pregnant, or are breast-feeding
  • If you drink alcohol or use drugs

How should I take clonidine?

Clonidine is usually taken one to two times per day with or without food.

The dose usually ranges from 0.1 mg to 0.4 mg per day. Only your health care provider can determine the correct dose for you.

Extended release tablets (Kapvay) should not be crushed, chewed or divided. Swallow the tablet whole.

What happens if I miss a dose of clonidine?

If you miss a dose of clonidine take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider. Do not double your next dose or take more than what is prescribed.

What should I avoid while taking clonidine?

Clonidine may cause dizziness or drowsiness, especially when first starting the medication. Make sure you know how you react to the medication before you drive, operate machinery, or participate in other activities that may be dangerous if you are not alert.

Avoid drinking alcohol or using illegal drugs while you are taking this medication. They may decrease the benefits (worsen your condition) and increase adverse effects (sedation) of the medication.

What happens if I overdose with clonidine?

If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.

Overdosing with clonidine may cause sleepiness, dizziness, low blood pressure and slow heart rate.

A specific treatment to reverse the effects of clonidine does not exist.

What are possible side effects of clonidine?

Common

  • Sleepiness, drowsiness, dizziness, headache, irritability
  • Low blood pressure
  • Nausea, stomach pain, dry mouth, constipation and decreased appetite

Rare

  • Very low blood pressure or heart rate
  • Fainting

Are there any risks for taking clonidine for long periods of time?

There are no known problems associated with long term use of clonidine. 

What other medications may interact with clonidine?                    

The following medications may increase the effects of clonidine:

  • Medications that lower blood pressure or cause sedation (sleepiness)
  • Other products containing clonidine or guanfacine (Tenex or Intuniv)

How long does it take for clonidine to work?

It may take four to eight weeks to get the maximum benefit once the right dose is determined. However, improvements in some symptoms may occur sooner. Your health care provider may also need to adjust gradually the dose to find the dose that works best for you.

Provided by the College of Psychiatric and Neurologic Pharmacists, January 2016