NAMI HelpLine

Psychosis

Early Or First-Episode Psychosis

Early treatment of psychosis and other symptoms of mental health conditions leads to the best outcomes.

Research has shown significant success using a treatment approach called Coordinated Specialty Care (CSC) for early or first episode psychosis. CSC uses a team of health professionals and specialists who work with a person to create a personal treatment plan based on life goals while involving family members as much as possible.

CSC has the following key components:

  • Case management
  • Family support and education
  • Psychotherapy
  • Medication management
  • Supported education and employment
  • Peer support

SAMHSA maintains an Early Serious Mental Illness (ESMI) Treatment Locator as a source of information for family members who are seeking CSC programs in the US. Portions of their website are available in Spanish. The Early Psychosis Intervention Network (EPINET) Clinic Map may also be helpful.

Psychosis Treatment

Traditional treatment for psychosis involves a combination of psychotherapy and medication. Several types of therapy have successfully helped individuals learn to understand and manage their condition. Medication targets specific symptoms and helps reduce their impact.

Medication

Antipsychotic medications help reduce hallucinations, delusions, and disorganized thinking. Finding the right medication and dose can take time. There are options available for those who prefer not to take a daily pill. Long-acting injectable (LAI) medications are an effective option that helps maintain steady treatment and reduce relapse risk. Different medicines have different side effect profiles, so be sure to understand them before beginning a medication. NAMI partners with the American Association of Psychiatric Pharmacists (AAPP) to provide information on mental health medications and help you learn what to expect and plan for with each one.

It’s important to specifically mention one medication — clozapine (Clozaril), a unique second-generation antipsychotic — because it is the only FDA-approved medication for treatment-resistant schizophrenia (TRS). It is also the only FDA-approved medication to reduce suicidality in people living with schizophrenia. Clozapine has additional blood monitoring requirements and side effects, but remains an underutilized resource for people who have not responded to treatment with at least 2 different antipsychotic medications. Clozapine has been shown to be the most effective medication in these cases.

With the help of families and individuals sharing their experiences, NAMI and other advocacy organizations successfully advocated for a reduction in paperwork and process to access clozapine at the FDA in 2025. This announcement signaled the removal of the risk evaluation and mitigation strategy (REMS) process, which eliminates some of the barriers to clozapine use.

Psychotherapy and Skills-Based Support

Therapy helps people make sense of their experiences, learn coping strategies, and strengthen social and occupational functioning. Family psychoeducation, social skills training, and supported employment or education programs also play an important role in recovery. Remember, the most effective treatments involve a combination of approaches.

Recovery and Long-Term Wellness

With early, person-centered care, many people who experience psychosis can manage their symptoms, continue school or work, and lead fulfilling lives. Recovery looks different for everyone — and having consistent support makes a meaningful difference. Some find peer support — both giving and receiving — to be essential elements of recovery. The NAMI Peer-to-Peer education program can provide compassion, understanding and support along this journey.

 

Reviewed and updated December 2025

NAMI HelpLine is available M-F, 10 a.m. – 10 p.m. ET. Call 800-950-6264,
text “NAMI” to 62640, or email. In a crisis, call or text 988 (24/7).